Tuam Tshoj 200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH Chaw tsim tshuaj paus thiab Hoobkas |Jiayinglai

200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH Featured duab

Tom ntej: 200124-22-7 Tert-butoxycarbonyl-arginine (Pbf)-OH

Lus piav qhia luv luv:

Qhov tshwm sim	Dawb rau Off-White crystals los yog crystalline hmoov.
MF	C24H38N4O7S
MW	526.65 ib
Purity	98+

Xa email rau peb

Product Detail

Kev thauj mus los & kev pom zoo shipping txoj kev:
los ntawm huab cua, los ntawm hiav txwv lossis los ntawm kev nthuav qhia

Kev cia khoom:
Muab ntim rau hauv qhuav, Khaws rau hauv lub freezer, hauv qab -20 ° C

Yam tsawg kawg nkaus Order Qty:
Kev sib tham

Ntawv pov thawj:
COA, HPLC, GC, HNMR, Assay, Dej Cov ntsiab lus (KF), TLC muaj

Synonyms

N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl)sulfonyl]amino]iminomethyl]-N2-BOC-L-ornithine;
Nα-Boc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl)-L-arginine;
Nalpha-Boc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-sulfonyl)-L-arginine;
BOC-ARGININE(PBF)-OH;BOC-L-ARG(PBF)-OH;
BOC-N-OMEGA-(2,2,4,6,7-PENTAMETYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE

Ntim sab hauv

Lawv feem ntau yog siv los ntim cov hmoov.Thiab lawv tuaj yeem tiv thaiv tshav ntuj thiab dej kom tsis txhob ua phem.

sab nrauv ntim

Lub thawv tawv tawv tuaj yeem tiv thaiv koj cov khoom los ntawm kev sib tsoo thiab ntub dej.

Daim ntawv thov

Boc-Arg (Pbf) -OH yog arginine derivative.
Bivalirudine, ib qho hluavtaws anticoagulant uas yog 20-peptide kwv tij txheeb ze ntawm hirudin, tau pom zoo muag hauv Tebchaws Meskas hauv xyoo 2000. Kev txhaj tshuaj yog tshuaj dawb, xoob lossis cov khoom amorphous.Bivarudine tuaj yeem khi tshwj xeeb rau thrombin catalytic site thiab anion sab nraud khi qhov chaw, thiab ncaj qha inhibit qhov kev ua ntawm thrombin, yog li inhibiting cov tshuaj tiv thaiv catalyzed thiab induced los ntawm thrombin, thiab nws cov nyhuv yog thim rov qab.Bivarudine feem ntau yog siv los ua anticoagulant rau xaiv percutaneous coronary intervention (PCI) rau cov neeg laus.
Bivarudine yog ib qho ncaj qha inhibitor ntawm thrombin, uas tshwj xeeb khi rau cov chaw catalytic thiab anion exo-binding qhov chaw ntawm thrombin dawb thiab ntawm thrombus.Cov txheej txheem khi ntawm bivaludine thiab thrombin yog thim rov qab, thiab thrombin tuaj yeem rov qab ua cov haujlwm lom neeg ntawm thrombin los ntawm maj mam enzymolysis ntawm peptide daim ntawv cog lus ntawm bivaludine Arg3-Pro4.
Cov kev tshawb fawb hauv vitro tau pom tias bivarudine tuaj yeem tsis tsuas yog cuam tshuam rau sab nraud dawb thrombin, tab sis kuj inhibit cov thrombin khi nrog cov ntshav txhaws yam tsis muaj kev cuam tshuam los ntawm cov tshuaj tso tawm los ntawm platelets.Nws tuaj yeem ncua sijhawm ib nrab ntawm lub sijhawm prothrombin (APTT), lub sijhawm thrombin (TT), lub sijhawm prothrombin (PT) thiab lub sijhawm ua haujlwm coagulation (ACT) ua haujlwm los ntawm cov ntshav plasma.Muaj kev sib raug zoo nrog cov concentration ntawm bivarudine, tab sis seb qhov kev sib raug zoo no puas muaj nyob hauv daim ntawv thov kho mob tsis paub meej.
Nws tau raug tshaj tawm nyob rau hauv cov ntaub ntawv hais tias cov tshuaj pharmacokinetics ntawm cov neeg mob nyob rau hauv percutaneous coronary angioplasty (PTCA) yog linear tom qab intravenously tswj ntawm bivarudine.Tus neeg mob tau muab 1 mg / kg intravenously raws li kev thauj khoom, tom qab ntawd los ntawm lwm qhov IV infusion ntawm 2.5 mg / kg / teev rau 4 teev, uas ruaj khov ntawm 12.3 ± 1.7 mg / ml hauv vivo.Bivarudine yog tshem tawm ntawm plasma los ntawm lub raum hydrolysis thiab protease degradation.Kev tshem tawm ib nrab-lub neej ntawm cov neeg mob uas lub raum ua haujlwm li qub yog li 25 feeb, thiab qhov kev tshem tawm ib nrab-lub neej ntawm cov neeg mob uas muaj lub raum tsis txaus thiab mob hnyav tau txuas ntxiv.Txog 25% ntawm bivarudine tuaj yeem raug tshem tawm los ntawm kev lim ntshav thiab tshem tawm los ntawm hemodialysis.ACT yuav tsum tau saib xyuas hauv cov neeg mob lub raum tsis zoo.Hauv cov neeg ua haujlwm noj qab haus huv, cov nyhuv anticoagulant tau pom tam sim tom qab txhaj tshuaj bivarudine, nrog rau PT, ACT thiab APTT ntev.Ib mus rau ob teev tom qab rho tawm, ACT rov qab mus rau qib ua ntej kev tswj hwm.

cov khoom muaj feem xyuam

Cbz-Phe-Arg-OH	Boc-L-Arg-OH.HCl
Arg-Tyr-Oet	Boc-L-Arg-OH.HCl.H2O
HL-Arg-OH	Boc-D-Arg-OH•HCl•H2O
HD-Arg-OH	Boc-Arg(Cbz)-OH
DL-Arg-OH	Fmoc-L-Arg-OH
L-Arg-Ome.2 Hcl	Fmoc-D-Arg-OH
D-Arg-Ome.2HCl	Fmoc-L-Arg(NO2)-OH
L-Arg(Pbf)-OH	Fmoc-L-Arg(Pbf)-OH
D-Arg(NO2)-OH / N-NO2-D-Arg	Fmoc-HoArg(Pbf)-OH
HL-Arg(NO2)-OH	Fmoc-Arg(Tos)-OH
HL-Arg(Tos)-OH	Fmoc-D-Arg(Tos)-OH
L-Arg-NH2	Fmoc-D-Arg(Pbf)-OH
Boc-L-Arg-OH	Cbz-Arg-OH
Boc-D-Arg (Pbf)	Cbz-D-Arg-OH
Boc-Arg-Oet	Cbz-L-Arg(Pbf)-OH
Boc-L-Arg-Ome	Cbz-D-Arg(pbf).CHA
Boc-L-Arg(Tos)-OH	Cbz-D-Arg-Gly-OH
Boc-L-Arg(NO2)-OH	L-Arg(Pbf)-Asp
Fmoc-L-HomoArg-OH	L-Homoarg.hcl

Superiority

1. R&D kev pabcuam muaj
2. ISO certified chaw tsim tshuaj paus, zoo guarantee
3.A tag nrho cov kev pabcuam tomqab muag thaum lub sijhawm tsim khoom
4.High nqi zoo
5.Cov ntaub ntawv pov thawj zoo muab rau ib tus neeg siv khoom thov
6.Kev pab cuam tom qab muag zoo, tswj kev sib raug zoo nrog cov neeg siv khoom
7.Ntau cov peev txheej los pab txo tus nqi thauj khoom
8.Dawb qauv muab los kuaj xyuas qhov zoo ua ntej kev them nyiaj
9. Lub sij hawm them nyiaj sib tham
10.Assit cov neeg muas zaub nrog cov xwm txheej hauv Suav teb