Tuam Tshoj 130622-05-8 Tert-butoxycarbonyl-D-glutamic acid (methyl ester)-methyl ester Chaw tsim tshuaj paus thiab Hoobkas |Jiayinglai

130622-05-8 Tert-butoxycarbonyl-D-glutamic acid (methyl ester)-methyl ester

Lus piav qhia luv luv:

Qhov tshwm sim	Dawb rau Off-White crystals los yog crystalline hmoov.
MF	C12H21NO6
MW	275.3 ib
Purity	98+

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Product Detail

Kev thauj mus los & kev pom zoo shipping txoj kev:
los ntawm huab cua, los ntawm hiav txwv lossis los ntawm kev nthuav qhia

Kev cia khoom:
Khaws nyob rau hauv qhov chaw tsaus, kaw hauv qhuav, Chav Kub

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Ntawv pov thawj:
COA, HPLC, GC, HNMR, Assay, Dej Cov ntsiab lus (KF), TLC muaj

Synonyms

dimethyl (tert-butoxycarbonyl)-D-glutamate;
(R)-2-tert-Butoxycarbonylamino-pentanedioic acid dimethyl ester;
(Tert-Butoxy) Carbonyl D-Glu (Ome) - Ome (Syrup);
Boc-D-Glu(Ome)-Ome (Syrup);
dimethyl (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino] pentanedioate;
Alogliptin impurity 43;
1,5-dimethyl (2R)-2-{[(tert-butoxy)carbonyl]amino}pentanedioate

Ntim sab hauv

Lawv feem ntau yog siv los ntim cov hmoov.Thiab lawv tuaj yeem tiv thaiv tshav ntuj thiab dej kom tsis txhob ua phem.

sab nrauv ntim

Lub thawv tawv tawv tuaj yeem tiv thaiv koj cov khoom los ntawm kev sib tsoo thiab ntub dej.

Daim ntawv thov

Fluoroquinolones muaj cov tshuaj tua kab mob dav dav, muaj zog tiv thaiv kab mob, tsis tshua muaj tshwm sim, cov ntaub so ntswg zoo permeability, siab bioavailability ntawm qhov ncauj, lub sijhawm ua haujlwm ntev thiab kev tswj xyuas yooj yim.Lawv feem ntau siv los kho cov kab mob sib kis xws li kab mob ua pa thiab kab mob urinary.Cov qauv ntawm cov tshuaj tua kab mob fluoroquinolone yog tus cwj pwm los ntawm qhov muaj fluorine nyob rau hauv thib rau txoj hauj lwm ntawm quinolone niam txiv nucleus.
Txawm li cas los xij, nyob rau hauv 10 xyoo tsis ntev los no, vim kev xaiv lub siab tsim los ntawm kev siv dav ntawm cov tshuaj no, cov tshuaj tiv thaiv kab mob nce ntxiv, tshwj xeeb tshaj yog nyob rau xyoo tas los no, quinolone-resistant Streptococcus pneumoniae muaj kev sib tw, uas tiv taus penicillin, macrolide tshuaj tua kab mob thiab quinolone tshuaj tua kab mob.Nyob rau tib lub sijhawm, nws tau pom tias qee cov fluoroquinolones tuaj yeem ua rau QTc ncua sijhawm ntawm electrocardiogram, hepatotoxicity thiab phototoxicity, uas txwv lawv daim ntawv thov.
Yuav kom kov yeej cov kev tsis txaus siab saum toj no ntawm fluoroquinolones, nws yog qhov tsim nyog los tsim cov txheej txheem tshiab nrog kev ua haujlwm zoo ntawm cov kab mob, cov kab mob dav dav thiab me me raws li qhov ua tau tsis zoo tiv thaiv kab mob ntau yam tshuaj tiv thaiv kab mob.Cov tshuaj tsis ntev los no tau tsim tawm tshiab fluoroquinolone-free (NFQ) cov tshuaj uas muaj 8-methoxyl txawv ntawm fluoroquinolone tshuaj tua kab mob uas lawv tsis muaj fluorine ntawm txoj hauj lwm 6 ntawm quinolone niam txiv nucleus, tab sis tseem muaj zog hauv vitro tshuaj tua kab mob.nemonoxacin yog ib qho tshiab NFQ xaiv kab mob topoisomerase inhibitor.
Piv nrog rau fluoroquinolones tam sim no nyob rau hauv kev ua lag luam, Nenofloxacin sawv cev rau cov chav kawm tshiab ntawm cov qauv tshuaj.nemonocacin (TG-873870), ib qho tshuaj quinolone tshiab tsim los ntawm Procter & Gamble (P&G), tau pom cov tshuaj tua kab mob tseem ceeb tiv thaiv ntau yam kab mob, suav nrog Staphylococcus aureus thiab multidrug-resistant Streptococcus pneumoniae.Cov txiaj ntsig ntawm kev sim hauv cov nas kis tau pom tias cov tshuaj tua kab mob ntawm cov khoom no muaj zog dua li feem ntau ntawm cov quinolones tam sim no.Tsis tas li ntawd, cov khoom lag luam muaj cov tshuaj pharmacokinetic zoo heev thiab tau txais txiaj ntsig zoo.

cov khoom muaj feem xyuam

Fmoc-Gly-glu(otbu)-oh	Boc-D-Glu(OBzl)-Oet
HL-Glu-OH	Boc-D-Glu(Obzl)-OH
HD-Glu-OH	Boc-D-Glu(Ome)-OH
DL-Glu-OH	Boc-D-Glu(Ome)-OH.DCHA
DL-Glu-OH.H2O	Boc-Glu(OBzl)-Obzl
L-Glu(Obzl)-NCA	Boc-L-Glu-OBzl
D-Glu(Obzl)-NCA	Boc-D-Glu-Obzl
DL-Glu(Obzl)-NCA	Boc-D-Glu-Otbu-OH
L-Glu-Obzl	Boc-D-Glu(OMe)-OMe
Tos-Glu-Obzl	Boc-D-Glu(Obzl)-Obzl
L-Glu(Ome)-Obzl.TOS	Boc-L-Glu(Ome)-Ome
AC-Glu (OtBu)	Boc-L-Glu(OMe)-OH
DL-Glu (Ome)	Boc-L-Glu(OBzl)-OH
HD-Glu(OMe)-OH	Boc-Glu-Otbu
HL-Glu(OMe)-OH	Boc-L-Glu(Obzl)-Ome
L-Glu (Obzl)	Boc-L-Glu (Oet)
HL-Glu(OtBu)-OH	Fmoc-L-Glu-OH
HL-Glu(OEt)-OH	Fmoc-D-Glu-OH
L-Glu(Otbu)-Otbu-OH	Fmoc-D-Glu(Ome)-OH
HD-Glu(OBzl)-OH	Fmoc-L-Glu(OcHx)-OH
D-Glu-OBzl	Fmoc-L-Glu(OMe)-OH
HL-Glu(Ome)-Otbu.Hcl	Fmoc-L-Glu(OtBu)-OH
D-Glu(Obzl)-Otbu.HCL	Fmoc-D-Glu(OBzl)-OH
D-Glu(OtBu)-OtBu•HCl	Fmoc-D-Glu(Otbu)-OH
L-Glu(OcHx).hcl	Fmoc-L-Glu-OtBu
HL-Glu(OBzl)-OBzl.HCl	Fmoc-L-Glu(OBzl)-OH
HL-Glu-OBzl.HCl	Fmoc-L-Glu (Cbz-yog)
D-Glu(OBzl)-OBzl.HCl	Fmoc-N-Me-L-Glu(Otbu)-OH
DL-Glu(Ome)-Ome.Hcl	Fmoc-glu-obzl
HL-Glu(OtBu)-OtBu•HCl	Cbz-L-Glu-OH
HL-Glu(OMe)-OMe.HCl	Cbz-D-Glu-OH
L-Glu(Obzl)-OME.HCL	ZL-Glu-OBzl
HL-Glu(OEt)-OEt · HCl	ZD-Glu-OBzl
L-Glu(Obzl)-Otbu.HCl	Cbz-L-Glu-Otbu
HD-Glu(OMe)-OMe·HCl	Cbz-D-Glu (ome)
N-Pht-Glu	Cbz-L-Glu(OBzl)-OH
Boc-L-Glu-OH	Cbz-L-Glu (Otbu)
Boc-D-Glu-OH	Cbz-L-Glu (Ome)
Boc-Glu(obzl)-NH2	Cbz-D-Glu(OtBu)-OH
Boc-Glu (trt)-OH	Cbz-L-Glu(Ome)-OtBu
Boc-L-Glu(OcHx)-OH	Cbz-L-Glu-OBzl.DCHA
Boc-L-Glu(OtBu)-OH	Cbz-L-Glu(Oet)-OH
Boc-Glu(Osu)-Otbu	Boc-Glu-Otbu (Osu)

Superiority

1. R&D kev pabcuam muaj
2. ISO certified chaw tsim tshuaj paus, zoo guarantee
3.A tag nrho cov kev pabcuam tomqab muag thaum lub sijhawm tsim khoom
4.High nqi zoo
5.Cov ntaub ntawv pov thawj zoo muab rau ib tus neeg siv khoom thov
6.Kev pab cuam tom qab muag zoo, tswj kev sib raug zoo nrog cov neeg siv khoom
7.Ntau cov peev txheej los pab txo tus nqi thauj khoom
8.Dawb qauv muab los kuaj xyuas qhov zoo ua ntej kev them nyiaj
9. Lub sij hawm them nyiaj sib tham
10.Assit cov neeg muas zaub nrog cov xwm txheej hauv Suav teb