Tuam Tshoj 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Chaw tsim tshuaj paus thiab Hoobkas |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Featured duab

Tom ntej: 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Lus piav qhia luv luv:

Qhov tshwm sim	Dawb rau Off-White crystals los yog crystalline hmoov.
MF	C16H22N2O6
MW	338.36 ib
Purity	98+

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Product Detail

Kev thauj mus los & kev pom zoo shipping txoj kev:
los ntawm huab cua, los ntawm hiav txwv lossis los ntawm kev nthuav qhia

Kev cia khoom:
Muab kaw rau hauv qhuav, Chav Kub

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Ntawv pov thawj:
COA, HPLC, GC, HNMR, Assay, Dej Cov ntsiab lus (KF), TLC muaj

Synonyms

(S)-ethyl 2-(tert-butoxycarbonylaMino)-3-(4-nitrophenyl)propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, ethyl ester

Ntim sab hauv

Lawv feem ntau yog siv los ntim cov hmoov.Thiab lawv tuaj yeem tiv thaiv tshav ntuj thiab dej kom tsis txhob ua phem.

sab nrauv ntim

Lub thawv tawv tawv tuaj yeem tiv thaiv koj cov khoom los ntawm kev sib tsoo thiab ntub dej.

Daim ntawv thov

Nidanib, nws yog tshuaj.Lub npe tshuaj 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland ntawm methyl] - 2 - oxygen -, methyl ester, (z) - Clinically, cov khoom no yog siv los kho idiopathic pulmonary fibrosis (IPF).
Nidanib tau kawm 1,529 cov neeg mob uas muaj idiopathic pulmonary fibrosis (IPF) hauv ntau qhov kev sim tshuaj.Cov ntaub ntawv kev nyab xeeb tau nthuav tawm yog raws li kev sib piv ntawm 1061 cov neeg mob tau muab nidanib 150 mg ob zaug ib hnub thiab cov placebo hauv ob 52-lub lim tiam theem 3, randomized, ob-dig muag, kev tshawb fawb placebo (INPULSIS-1 thiab INPULSIS-2).Cov xwm txheej tsis zoo uas tshwm sim feem ntau cuam tshuam nrog kev siv nidanib suav nrog raws plab, xeev siab thiab ntuav, mob plab, tsis qab los noj mov, poob phaus, thiab nce siab enzymes.Thov xa mus rau [Cov Lus Ceeb Toom] rau kev tswj xyuas qhov cuam tshuam tsis zoo.Qhov Systematic Organ Classification (SOC) ntawm MedDRA muab cov ntsiab lus ntawm cov kev cuam tshuam tsis zoo thiab kev faib tawm zaus.
Nidanib yog substrate rau P-gp (saib Pharmacokinetics).Hauv kev tshawb fawb tshwj xeeb ntawm kev sib cuam tshuam ntawm cov tshuaj, kev sib xyaw ua ke ntawm ketoconazole, muaj zog P-gp inhibitor, nce kev cuam tshuam rau nidanib mus rau 1.61 npaug ntawm thaj tsam hauv qab nkhaus (AUC) thiab 1.83 zaug los ntawm qhov siab tshaj plaws (Cmax).
Hauv kev tshawb fawb txog kev siv tshuaj nrog cov muaj zog P-gp inducer rifampicin, raug rau nidanib txo mus rau 50.3%, raws li ntsuas los ntawm cheeb tsam hauv qab nkhaus (AUC), thaum ua ke nrog rifampicin piv nrog Nidanib ib leeg.Los ntawm qhov siab tshaj plaws concentration (Cmax), nws txo mus rau 60.3%.
Thaum noj ua ke nrog cov khoom no, muaj zog P-gp inhibitors (piv txwv li, ketoconazole lossis erythromycin) tuaj yeem ua rau muaj kev cuam tshuam rau nidanib.Hauv cov xwm txheej no, tus neeg mob lub siab ntev rau nidanib yuav tsum tau saib xyuas zoo.Kev tswj xyuas qhov tsis zoo yuav xav tau kev txiav tawm, txo koob tshuaj, lossis txiav kev kho nrog cov khoom no (saib [Siv thiab ntau npaum li cas]).
P-gp muaj zog inducers (xws li, rifampicin, carbamazepine, phenytoin thiab St. John's wort) tuaj yeem txo qhov raug nidanib.Lwm txoj kev ua ke nrog tsis muaj lossis tsawg tsawg P-gp induction yuav tsum raug txiav txim siab.

cov khoom muaj feem xyuam

Gly-Pheej	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Ph
Boc-D-4-Chloropheny (Alanine)	Fmoc-L-Ph-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Ph-OH	Fmoc-D-Ph-OH	4-NO2-Ph-Oet	Boc-L-Phe-Onp
Boc-Ala-Ph-OH	Fmoc-N-Me-L-Ph-OH	4-NO2-Ph-Oet.HCl	Boc-L-Ph-Oet
Boc-Ala-Ph-OH	FMOC-N-Me-D-Ph-OH	HD-Ph-Ome · HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Ph(4-NO2)-OH
Leu-Phe. Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Ph-OBzl .tos	Fmoc-Phe-Ph-OH
Boc-Leu-Phe	Cbz-L-Ph-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Ph-Leu-OH	Cbz-D-Ph-OH	HL-Phe-OBzl.HCl	Fmoc-D-Ph(4-NO2)-OH
L-Pheej	Cbz-DL-Ph-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Ph-OH	Cbz-D-Phe-OL	L-Ph-NH 2	Cbz-Ph-Ala-OH
L-Phe-NCA	ZN-Me-L-Ph-OH	D-Ph-NH 2	Cbz-Phe-Gly-OH
Tos-Ph	cbz-L-Ph-OSU	N-Ac-L-Ph-OH	Cbz-Phe-Met-OH
L-Ph-ol	Pheej-Ala	N-AC-L-Ph-Ome	Cbz-Phe-Gly-Oet
L-Ph (4-NO2)-OH	L-Pheej	N-Pht-Ph-OH	Boc-Phe-Gly-Gly-OH
L-Ph (4-NO2) H2O	L-Ph-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Ph-OH
D-Phe(4-NO2)-OH.h2o	L-Ph-Leu-OH	Boc-D-Ph-OH	D-Ph-NH 2
D-Ph(4-NO2)-OH	L-Ph-Tyr-OH	Boc-DL-Ph-OH	Tyr-Phe
N-Me-D-Ph	L-Pheej-Gly	BOC-N-Me-D-Ph-OH	DL-Phe-Ome.Hcl
HN-Me-L-Ph-OH	D-Ph-D-Ph	Boc-N-Me-DL-Ph-OH	Boc-Met-Leu-Ph
L-Phe.hcl	L-Ph-OBzl-OH	Boc-N-Me-L-Ph-OH	Asp-Ph-Ome
4-NO2-D-phe.hcl	D-Ph-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homphe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homphe-OH
HD-Ph-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Ph-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Ph	Boc-D-Phe-Ome	Fmoc-L-homoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Ph-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Superiority

1. R&D kev pabcuam muaj
2. ISO certified chaw tsim tshuaj paus, zoo guarantee
3.A tag nrho cov kev pabcuam tomqab muag thaum lub sijhawm tsim khoom
4.High nqi zoo
5.Cov ntaub ntawv pov thawj zoo muab rau ib tus neeg siv khoom thov
6.Kev pab cuam tom qab muag zoo, tswj kev sib raug zoo nrog cov neeg siv khoom
7.Ntau cov peev txheej los pab txo tus nqi thauj khoom
8.Dawb qauv muab los kuaj xyuas qhov zoo ua ntej kev them nyiaj
9. Lub sij hawm them nyiaj sib tham
10.Assit cov neeg muas zaub nrog cov xwm txheej hauv Suav teb