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3339-73-9 3-Phthalimidopropionic acid

3339-73-9 3-Phthalimidopropionic acid

Lus piav qhia luv luv:

Qhov tshwm sim Dawb rau Off-White crystals los yog crystalline hmoov.
MF C11H9NO4
MW 219.19 Nws
Purity 98+


Product Detail

Kev thauj mus los & kev pom zoo shipping txoj kev:
los ntawm huab cua, los ntawm hiav txwv lossis los ntawm kev nthuav qhia

Kev cia khoom:
Muab kaw rau hauv qhuav, Chav Kub

Yam tsawg kawg nkaus Order Qty:
Kev sib tham

Ntawv pov thawj:
COA, HPLC, GC, HNMR, Assay, Dej Cov ntsiab lus (KF), TLC muaj

D-Lys(tfa)-NCA (2)

Synonyms

3-PHHALIMIDOPROPIONIC ACID;
Pht-b-Ala-OH;
3-Phthalimidopropionic acid, 97+%; 1,3-Dihydro1,3-dioxo-2H-isoindole-2-propanoic acid;
3-(1,3-Dioxoisoindoline-2-yl) propanoic acid; 3Phthalimidylpropanoic acid;
3-Phthalimidylpropionic acid; N, N-Phthaloyl-β-alanine;
3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid (SALTDATA: DAWB)

Ntim sab hauv

Lawv feem ntau yog siv los ntim cov hmoov.Thiab lawv tuaj yeem tiv thaiv tshav ntuj thiab dej kom tsis txhob ua phem.

Sab hauv ntim 2
Inner packing 1
Inner packing 3

sab nrauv ntim

Lub thawv tawv tawv tuaj yeem tiv thaiv koj cov khoom los ntawm kev sib tsoo thiab ntub dej.

Kev ntim khoom sab nrauv 3
Kev ntim khoom sab nrauv 2
Kev ntim khoom sab nrauv 1

Daim ntawv thov

1.1;2.1 1. Synthesis ntawm phthalic anhydride alanine: Ntxiv 100g (1.12mol) ntawm alanine mus rau 1000mL peb-caj dab, 170g (1.15mol) ntawm phthalic anhydride, 5g ntawm triethylamine thiab 650mL ntawm toluene tau sib cais, dej tau sib cais. Thaum lub sij hawm cov tshuaj tiv thaiv, cov tshuaj tiv thaiv tau nqa tawm mus txog rau thaum tsis muaj dej te, qhov kub thiab txias yog txo mus rau 20 ° C, qhov kub thiab txias yog khaws cia rau 2 teev, nqus pom, lim ncuav ci ncuav qhuav qhuav 240.2 g ntawm phthalic anhydride alanine, HPLC purity 99.1%, yield 97.7%.
I-16.1 Synthesis ntawm 3-(l,3-dioxo-2,3-dihydro-lH-isoindol-2-yl) propanoic acid Rau hauv 3-L 4-caj dab puag ncig-hauv qab lub raj mis purged thiab tswj nrog ib qho chaw inert ntawm nitrogen, tau muab tso rau hauv kev daws ntawm 3-aminopropanoic acid (20 g, 224.48 mmol, 1.00 equiv) thiab 1,3- dihydro-2-benzofuran-l, 3-dione (33.28 g, 224.69 mmol, 1.00 equiv) hauv acetic acid. (1,200 mL).Qhov no tau ua raws li qhov sib ntxiv ntawm cov poov tshuaj acetate (66.0 g, 672.49 mmol, 3.00 equiv) hauv ntau pawg ntawm 0 ° C.Lub resulting tov yog stirred rau 3 h ntawm 80 ° C nyob rau hauv ib tug roj da dej.Lub resulting sib tov yog concentrated nyob rau hauv lub tshuab nqus tsev vacuum.Tom qab ntawd cov tshuaj tiv thaiv yog quenched los ntawm qhov sib ntxiv ntawm 150 mL dej.Cov khib nyiab tau sau los ntawm kev pom.Qhov no ua rau 40 g (81%) ntawm 3-(l ,3-dioxo-2,3- dihydro-lH-isoindol-2-yl) propanoic acid ua cov khoom dawb.R/.0.15 (hauv ethyl acetate: roj av ether = 1: 1)
Kev sib xyaw ntawm β-alanine (5.0 g, 0.056 mol), phthalic anhydride (8.7 g, 0.059 mol), thiab DMF (20 mL) tau refluxed hauv qab nplawm rau 3 teev.Lub resulting sib tov yog txias rau chav tsev kub, ncuav rau hauv dej khov dej (~ 100 mL), thiab ces lim los ntawm suction.Lub ncuav mog qab zib lim tau ua ntu zus nrog dej (15 mL × 3), cawv (3 mL × 3), thiab ether (10 mL × 2), thiab tom qab ntawd qhuav hauv lub tshuab nqus tsev kom muab 2e (9.9 g, 80%) raws li cov xim dawb. khov kho.
137.6 Kauj Ruam 6: Kev sib xyaw ntawm isobenzofuran-l, 3-dione (20 g, 135 mmol) thiab 3-aminopropanoic acid (12 g, 135 mmol) tau nplawm ntawm 170 ° C rau 6h.Saib daim duab 2. Thaum cov tshuaj tiv thaiv ua tiav, cov khoom sib tov tau diluted nrog dej thiab muab rho tawm nrog DCM (100 mL x 3).Cov khaubncaws sab nraud povtseg ntawm cov organic sib xyaw tau qhuav dhau los ntawm anhydrous sodium sulfate, lim, thiab concentrated nyob rau hauv qhov txo qis kom muab 3-(l,3-dioxoisoindolin-2-yl) propanoic acid 137g (20 g, 69%) ua cov khoom dawb.
3-Phthalimidopropanoic acid (4) Ib qho sib xyaw ntawm phthalic anhydride (0.32 g, 2.2 mmol) thiab b-alanine (0.19 g, 2.2 mmol) tau muab tso rau hauv lub khob qhib rau 150˚C rau 2 teev.Tom qab txias rau rt, H2O (5 mL) tau ntxiv thiab cov tshuaj tiv thaiv sib xyaw tau muab rho tawm hauv CH2Cl2 (2 X 20 mL).Cov txheej txheem organic tau qhuav dhau Na2SO4, lim thiab muaj zog kom muab cov khoom dawb (0.3 g) hauv 62% tawm los;IR (KBr) 1711, 2954 cm-1;mp140-141˚C.Cov khoom siv tau siv rau hauv cov kauj ruam tom ntej yam tsis muaj kev lim dej ntxiv.

cov khoom muaj feem xyuam

Gly-Ala-Ome.hcl fmoc-β-Ala-osu DL-Ala-Otbu.Hcl Boc-Ala-Ala-Ome
Gly-Gly-Ala-Ome.hcl Cbz-L-Ala-OH L-Ala-NH2.HCl Boc-Ala-Ala-Obzl
L-ALA Cbz-D-Ala-OH HD-Ala-NH2 · HCl Fmoc-Ala-pro
DL-UA Cbz-N-Me-L-Ala-OH HD-Ala-NH2 Fmoc-Ala-gly-OH
H-Ala-ol Cbz-N-Me-D-Ala-OH Ac-L-Ala-NH2 Fmoc-L-Ala-Ala-OH
β-Ala-ol Cbz-DL-Ala-OH Ac-D-Ala-NH2 Fmoc-β-Ala-D-phe
D-ALa Z-β-L-Ala-OH AC-D, L-Ala-OH Fmoc-β-Ala-D-Tyr (Et)
H-β-Ala-OH Cbz-L-Ala-OL Ac-D-Ala-OH Cbz-Ala-Val-OH
HN-Me-L-Ala-OH Cbz-L-Ala-NH2 AC-L-Ala-OH Cbz-L-Ala-Ala-OH
HN-Me-D-Ala-OH Cbz-L-Ala-Ome AC-L-Ala-OME Cbz-Ala-Pro-OH
L-Ala-NCA Cbz-D-Ala-OMe Pht-D-Ala Cbz-L-Ala-Leu-OH
D-Ala-NCA Cbz-Beta-Ala-Ome Pht-L-Ala Cbz-L-Ala-Ala-Ome
L-Ala-nbu.hcl Cbz-β-Ala-Otbu Boc-L-Ala-OH Ala-Ala-Ome.HCL
L-Ala-Otbu Cbz-L-Ala-Osu Boc-D-Ala-OH Val-Ala
D-ALA-Oipr.HCL Cbz-Beta-Ala-OSU Boc-DL-Ala-OH Boc-Ala-Pro
D-Ala-Otbu.Hcl Ala-Ala-OH Boc-β-Ala-OH Boc-Val-Ala
N-Me-L-Ala-OMe Ala-gly Boc-N-Me-Ala-OH Cbz-Val-Ala-OH
HD-Ala-OBzl · HCl L-ALA-Val-OH Boc-N-Me-DL-Ala-OH Cbz-Val-Ala-Ome
β-Ala-Obzl.Tos L-Ala-Ph-OH Boc-N-Me-D-Ala-OH Leu-Ala-OH
H-Ala-OBzl · HCl L-Ala-Leu-OH Boc-L-Ala-Ol Boc-Leu-Ala
HL-Ala-OBzl.Tos-OH L-Ala-Pro-OH Boc-D-Ala-Ol Fmoc-leu-ala
HD-Ala-Oet.HCl DL-Ala-DL-Val Boc-DL-Ala-Ol Cbz-Leu-Ala-OH
HL-ALA-Oipr.HCL Ala-Gly-Ome.hcl Boc-Ala-NH2 Pheej-Ala
N-Me-Ala-Otbu.Hcl L-Ala-Ala-Obzl.HCl Boc-D-Ala-NH2 Boc-Phe-Ala-OH
HL-Ala-OtBu · HCl D-Ala-D-Ala-Ome.Hcl Boc-β-Ala-NH2 Cbz-Ph-Ala-OH
H-DL-Ala-OMe.HCl H-Ala-Ala-Otbu.HCL Boc-D-4-Chloropheny (Alanine) HL-Thr-OBzl·oxalate
β-Ala-Oet.HCl Boc-Ala-Ph-OH Boc-D-3 (1-Naphthgl)-alanine HL-Thr(Bzl)-OBzl.oxalate
N-Me-L-Ala-Ome.hcl Boc-L-Ala-Leu Boc-L-Ala-Ome Z-Lys(boc)-Ala-Ala-OBzl
HD-Ala-Ome.Hcl Boc-ALa-Val-OH Boc-D-Ala-OMe Fmoc-L-Ala-OH
β-Ala-Ome.HCl Boc-Ala-Pro Boc-L-Ala-Otbu Fmoc-DL-Ala
HL-Ala-Ome.Hcl Boc-Ala-Gly-OH Boc-L-ALA-OBZL Fmoc-D-Ala-OH
β-Ala-Otbu.HCl Boc-Ala-Ala-OH Boc-L-Ala-OSu Fmoc-β-Ala-OH
Fmoc-L-Ala-OH.H2O Fmoc-Ala-Cl Boc-L-Beta-Ala-Osu Fmoc-LN-Me-Ala-OH
Fmoc-Ala-Ome Fmoc-L-Ala-Ol Boc-D-Ala-OSu Fmoc-N-Me-D-Ala-OH
Fmoc-Ala-Osu fmoc-β-Ala-NH2

Superiority

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4.High nqi zoo
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7.Ntau cov peev txheej los pab txo tus nqi thauj khoom
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9. Lub sij hawm them nyiaj sib tham
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