22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide tseem hu ua Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, thiab ipratropium bromide.Nws yog dawb crystalline hmoov nrog iab saj.Melting point 232 ℃ -233 ℃.Soluble nyob rau hauv dej, me ntsis soluble nyob rau hauv ethanol, insoluble nyob rau hauv lwm cov organic solvents.Lub npe tshuaj: Brominated α-(hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Nws yog ib qho tshuaj anticholinergic, uas muaj zog so ntawm cov leeg nqaij bronchial thiab cov nyhuv antiasthmatic ntawm cov kab mob pulmonary ntev.Nws cov nyhuv yog pom tseeb, cov nyhuv sai thiab ntev ntev.Ipratropium bromide kuj tswj kev tso tawm ntawm cov qog ua kua thiab txhim kho ciliary txav, yog li txo cov hnoos qeev los txhim kho qhov cua.Meanwhile, txo cov hnoos qeev kuj alleviates bronchospasm los ntawm bronchial irritation.Rau kev tiv thaiv thiab kev kho mob ntawm bronchial hawb pob thiab mob ntsws asthmatic mob ntev, tshwj xeeb tshaj yog rau cov neeg mob uas tsis tuaj yeem zam kev siv β-agonist leeg tshee, tachycardia.Cov khoom no tuaj yeem siv ua ke nrog beta-agonists los txhim kho kev ua tau zoo ntawm ib leeg, xws li ua ke nrog finoterol los ua ib qho aerosol (BERODU - AL) rau kev mob hawb pob, mob ntsws ntev thiab emphysema.Piv nrog rau β-adrenergic receptor stimulants (xws li, isopropyl epinephrine), cov khoom no muaj tsawg dua cov kev mob plawv, thiab piv nrog β2-receptor stimulants (piv txwv li, Suquanling), cov khoom no muaj kev tswj xyuas muaj zog ntawm phlegm ntim.
Txau inhalation.40 ~ 80μg ib zaug, 2 ~ 4 zaug ib hnub.Thaum siv, ua ntej tshem lub hau npog lub hau, muab lub hau npog npog qhov muag ntawm lub nozzle, tig lub raj mis rau pem hauv ntej, muaj lub plhaub npog hauv lub qhov ncauj, tsom rau ntawm caj pas, nqus cov roj tib lub sijhawm, nias lub nozzle. ntawm lub valve, nqus tau cov kua, tuav koj ua pa ib pliag.Rov ua dua cov snap saum toj no ib zaug yog tias tsim nyog.Aerosol: 0.025% tov.Tablet: 10 mg/tab.
Cov tshuaj tiv thaiv anticholinergic hnyav tuaj yeem kho nrog cholinesterase inhibitors.
Cov tshuaj tiv thaiv tsis zoo ntawm ipratropium bromide zoo ib yam li atropine, uas tuaj yeem ua rau palpitation, mob taub hau, kiv taub hau, ntxhov siab, xeev siab, ntuav, mob plab, tshee, tsis pom kev, qhov ncauj qhuav, hnoos, dysuria, ua rau ua pa nyuaj thiab ua pob liab liab.
Ipratropium bromide yog muscarinic antagonist, bronchodilator, thiab isopropyl ntsev ntawm AtropineN.
Ipratropiumbromide thiab Formoterol ua ke ib feem los tiv thaiv lub ntsws los ntawm kev mob ntev thiab ua kom lub ntsws loj, txo cov neutrophils los ntawm inhibiting kev ua ntawm MMP-9.Ipratropiumbromide (1nM) nce cov calcium bromide, txo kev tawg rau pem hauv ntej thiab nce annexin-V binding.Tom qab kev kho mob Ipratropiumbromide, hemolysis nce me ntsis tab sis tseem ceeb.Ipratropiumbromide ua rau cov qe ntshav liab tuag los yog eryptosis, feem ntau vim yog calcium stimulation.
Ipratropium qhuav hmoov inhalation (DPI) yog ib qho zoo bronchodilator nyob rau hauv so nees ntawm ib koob ntawm 2400 mg / nees, nrog me ntsis cuam tshuam rau sab sauv caliber thaum lub sij hawm rov qab.Hauv cov nas uas kho cadmium, Ipratropium ua rau txo qis parenchymal inflammatory cell inflow thiab pom muaj neeg coob coob ntawm cov mob ntsws.Ipratropium ib feem tiv thaiv lub ntsws los ntawm kev mob los ntawm kev txo qis neutrophil infiltration.Hauv guinea npua tracheal du nqaij, Ipratropium yog ib qho antagonist uas inhibits prebound muscarinic inhibitory receptor ntawm lub ntsws parasympathetic paj hlwb.Ipratropium kuj tau pom tias yog lub zog antagonist tom qab khi rau muscarinic inhibitory receptors.Ipratropium txo qhov kev hloov pauv siab tshaj plaws hauv siab thiab ua kom muaj zog ua raws (Cdyn) hauv tidal respiration (incremental Pplmax) thiab pulmonary resistance (RL) hauv nees.