166108-71-0 Fmoc-AEEA-OH

166108-71-0 Fmoc-AEEA-OH yog ib tug cleavable ADC linker siv nyob rau hauv lub synthesis ntawm antibody-drug conjugates (ADCs).Fmoc-8-amino-3,6-dioxaoctanoic acid kuj yog PEG-based PROTAC linker uas tuaj yeem siv rau hauv kev sib txuas ntawm PROTACs.

166108-71-0 Fmoc-AEEA-OH kuj tuaj yeem yog ib qho ntawm Semaglutide Intermediates.

Cov txiaj ntsig tseem ceeb ntawm semaglutide yog kho mob ntshav qab zib hom 2 los ntawm kev txo cov ntshav qabzib.Nws ua raws li cov tshuaj insulin zoo li peptide-1, uas ua rau cov tshuaj insulin tso tawm thiab inhibits glucagon tso tawm, yog li txo qis cov ntshav qabzib.Semaglutide tsis ua rau muaj kev pheej hmoo ntawm hypoglycemia tshwm sim piv rau kev kho cov tshuaj insulin vim tias nws cov txheej txheem ntawm kev ua haujlwm yog qhov nyuaj thiab meej.Los ntawm kev kho qhov sib npaug ntawm insulin thiab glucagon, somalutide tuaj yeem pab cov neeg mob ntshav qab zib hom 2 kom tswj tau lawv cov ntshav qab zib kom zoo.

Ntxiv nrog rau kev txo qis cov ntshav qab zib, semaglutide tuaj yeem txo lub cev hnyav.Qhov no yog vim nws qab los noj mov suppressant nyhuv.Semaglutide txhawb kev ua haujlwm ntawm qhov chaw satiety hauv hypothalamus, uas txo qis qab los noj mov.Qhov txiaj ntsig tseem ceeb ntawm semaglutide tshaj lwm cov tshuaj poob phaus yog tias nws poob qhov hnyav thaum txhim kho insulin tsis kam thiab tswj ntshav qab zib.Qhov no ua rau nws yog qhov kev xaiv zoo tshaj plaws rau kev kho mob rau cov neeg mob ntshav qab zib uas muaj rog rog.

Tsis tas li ntawd, semaglutide txhim kho pancreatic muaj nuj nqi thiab txo cov inflammatory teb nyob rau hauv pancreatic islet hlwb.Nws tiv thaiv islet cells los ntawm kev puas tsuaj ntxiv los ntawm ntshav qab zib thiab txhawb nqa islet cell regeneration.Qhov no yog qhov tseem ceeb tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib hom 2, vim tias ntau cov islet cell puas tuaj yeem ua rau islet tsis ua haujlwm.

Zuag qhia tag nrho, semaglutide yog ib qho tshuaj zoo heev thiab nyab xeeb rau kev kho mob ntshav qab zib hom 2.Nws pab cov neeg mob zoo tswj lawv cov ntshav qab zib thiab txo cov teeb meem los ntawm kev txo cov ntshav qabzib, txo lub cev hnyav, txhim kho islet muaj nuj nqi, thiab tiv thaiv islet hlwb.Cov kev tshawb fawb yav tom ntej yuav tshawb fawb ntxiv txog qhov muaj peev xwm ntawm somatostatin hauv kev kho mob ntawm lwm yam kab mob, xws li NAFLD thiab rog rog.